United could fall a staggering 30 points behind leaders Liverpool if they are beaten at Anfield.
On the rivalry, Maguire said: "When they're fighting at the top for so many trophies like they have been doing, it's something that builds that rivalry.
"I've felt it since I've been here, the rivalry between the two clubs. Sunday is a big game, there's no doubt about it, and one we're looking forward to.
"We're not going there to play for a draw and wherever we go, we're expected to win games because we're Manchester United . We have confidence in our ability and our team."